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Gardasil 9 is as effective as Gardasil for the prevention of diseases caused by the four shared HPV types (6, 11, 16, and 18), based on similar antibody responses in participants in clinical studies.The trials that led to approval of Gardasil 9 found it to be nearly 100% effective in preventing cervical, vulvar, and vaginal disease caused by the five additional HPV types (31, 33, 45, 52, and 58) that it targets (4).
The Cervarix vaccine has been found to provide partial protection against a few additional HPV types not included in the vaccine that can cause cancer, a phenomenon called cross-protection (6).For example, researchers estimate that Gardasil 9 could reduce the number of new anal cancers by 90% (9).Before any vaccine is licensed, the FDA must determine that it is both safe and effective.All three HPV vaccines have been tested in tens of thousands of people in the United States and many other countries.
Thus far, no serious side effects have been shown to be caused by the vaccines.
HPV vaccines are highly effective in preventing infection with the types of HPV they target when given before initial exposure to the virus—which means before individuals begin to engage in sexual activity.