Elucidating the mechanism of cellular uptake and removal of protein
Cells exposed to Group 2, including Mo and Sn, although initially attached and grew, did not proliferate over time. S., Wen, C., and Li, Y., Cellular responses of osteoblast-like cells to 17 elemental metals, Journal of biomedical materials research. Nickel (Ni) eluted from metallic biomaterials is widely accepted as a major cause of allergies and inflammation.
In contrast, Group 3, including V, Mn, Fe, Co, Ni, Cu, and Zn, showed severe cytotoxicity toward Sa OS2 cells. To improve the safety of cobalt-chromium-molybdenum (Co-Cr-Mo) alloy implants, new ultralow-Ni Co-Cr-Mo alloys with and without zirconium (Zr) have been developed, with Ni contents of less than 0.01%.
Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education, College of Animal Science, Guizhou University, Guiyang 550025, China 2.
Soft Condensed Matter Laboratory, College of Science, Guizhou University, Guiyang 550025, China 3.
State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China 4.
Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China 5.
Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle.
The amount of Mo-99 produced was compared to that predicted by calculation using the particles and heavy ion transport code system.
Our study, suggests that the present ultralow-Ni Co-Cr-Mo alloys with and without Zr have greater safety and utility than conventional Co-Cr-Mo alloys. Metals and alloys need hence to be investigated on their extent of released metals (bioaccessibility) in biologically relevant environments.